Clinicopathological characteristics, treatment patterns, and outcomes in patients with laryngeal cancer
Abstract: Background: Various factors can affect the survival of patients with laryngeal cancer (LC).
In this retrospective study, we assessed clinicopathological features, their prognostic value, and
treatment modalities for patients with confirmed squamous cell LC. Methods: We collected patient
data on demographics, clinicopathological characteristics, treatment patterns, and outcomes. The
primary endpoints were overall survival (OS), disease-specific survival (DSS), disease-free survival
(DFS), and locoregional control (LRC). We assessed survival using the Kaplan–Meier method and
Cox regression model analyses of potential prognostic parameters. Results: After a median follow-up
of 76 months, 28 (33.3%) patients had a recurrence. The median OS was 78 months, with an event
recorded in 50% of patients. The DSS median was not reached (NR) with a survival rate of 72.6%, the
DFS survival rate was 66.7% with median NR, and the LRC survival rate was 72.6% with median
NR. After conducting a multivariate analysis of significant variables, we found that only recurrence
and lymphatic invasion had an independent effect on OS and recurrence in DSS, while subsite
impacted DFS and LRC. Conclusions: Survival trends were consistent with other studies, except
for OS. Recurrence, lymphatic invasion, and subsite location were significant factors that impacted
patient survival.