Background/Aim. Cardiovascular diseases are the most
common cause of mortality and morbidity worldwide,
with the highest incidence in low-middle-income countries.
Dobutamine stress echocardiography (DSE) plays a
significant role in diagnosing coronary artery disease. The
aim of the study was to examine the influence of gender
on the accuracy of DSE and on the prognostic significance
of the left ventricular wall motion score index
(WMSI) as a parameter of DSE for adverse cardiovascular
events (ACEs). Methods. The prospective, observational
study conducted at the Clinic for Cardiovascular
Diseases of the University Clinical Center of the Republic
of Srpska, Bosnia and Herzegovina, included 143 patients
who, due to suspicion of coronary disease, underwent
a DSE from January 1, 2021, until February 1,
2022. ACEs that we observed one year after DSE were:
unstable angina, acute myocardial infarction, percutaneous
coronary intervention, in-stent restenosis, aortocoronary
bypass, heart failure, and death. Results. A positive
DSE was more common in men (45%) compared to
women (25%), which was statistically significant
(p < 0.05). The sensitivity of the test in men was 96.0%,
and the specificity was 93.9%. In women, the sensitivity
was 86.7%, and specificity was also 86.7%. ACEs were
more frequent in men (43%) than in women (19%),
which was statistically significant (p < 0.01). In men,
WMSI had a sensitivity of 96.0% and a specificity of
82.4%. In women, WMSI had a sensitivity of 93.3% and
a specificity of 90.6% in predicting ACEs. Conclusion.
Our results confirmed the influence of gender on the accuracy
of DSE in diagnosing coronary artery disease.
WMSI as a parameter of DSE was identified as a signif icant
prognostic factor for ACEs in both sexes, with the
sensitivity being higher in men and specificity in women.
